Chen was born in Taipei, Taiwan on the 4th of July and emigrated to the United States in late 1994. Working professionally in the Asian comic book industry since age 18, she burst suddenly onto the U.S. comic book scene with her art work for the Racer X mini-series, part of the Speed Racer series published by Wildstorm/D.C. Comics in 2000.
She quickly established herself producing interiors and covers for titles including Darkminds Macropolis, Battle of the Planets, Robotech, Fight For Tomorrow, Taskmaster, The Demon, Thor, and (Batman &) Robin. Currently she is most well-known to American comic readers as the cover artist of Runaways.
In June 2006, Joss Whedon announced that Chen would illustrate the covers to the upcoming Buffy the Vampire Slayer 'season 8 comic.
In other media, Chen has also produced packaging artwork for Microsoft's popular FABLE and FABLE: TLC RPGs, and done covers for PlayStation Magazine (a Final Fantasy cover for the January 2002 issue and a Tomb Raider cover for the February 2003 issue).
She is the younger sister of artist Christina Chen and lives with her family outside of Washington, D.C.