James Romberger has drawn comics for Marvel's Epic Illustrated, Image Comics, NBM/Papercutz and DC's Paradox Press. His DC/Vertigo works include the Renegade storyline from 2020 Visions; Hellblazer; the anthology titles Weird War, Gangland and Strange Adventures; and the graphic novels Bronx Kill with Peter Milligan and Aaron and Ahmed with Guggenheim fellow Jay Cantor.
Romberger's ecological comic Post York was published in 2012 by Uncivilized Books; it includes a flexi-disc of a song by his son Crosby and it was nominated for an 2013 Eisner Award for Best Single Issue (or One-Shot). A revised edition of Romberger and Marguerite Van Cook's critically acclaimed graphic novel 7 Miles a Second, done in collaboration with the late AIDS activist David Wojnarowicz, was published in in 2013 by Fantagraphics Books. In 2014 Fantagraphics published The Late Child and Other Animals, a graphic memoir written and colored by Van Cook and adapted and drawn by Romberger.